Dapoxetine and the treatment of premature ejaculation

Dapoxetine has a Tmax of 1.4–2.0 h and rapidly achieves peak plasma concentration (Cmax) following oral administration. The mean half life of dapoxetine after a single dose was estimated using modelling as 1.3–1.5 h. Dapoxetine plasma concentrations rapidly decline to about 5% of Cmax at 24 h. The terminal half life of dapoxetine was 15–19 h after a single dose and 20–24 h after multiple doses of 30 and 60 mg respectively. An analysis of pooled phase III data confirms that dapoxetine 30 and 60 mg increased IELT and improved patient-reported outcomes (PROs) of control, ejaculation-related distress, interpersonal distress and sexual satisfaction compared with placebo. Preclinical safety pharmacology studies did not suggest an adverse electrophysiologic or hemodynamic effect with concentrations of dapoxetine up to twofold greater than recommended doses.

At 24 hours following the last dose on day 9, there is 5.5% and 6.6% of peak plasma dapoxetine concentrations left in the blood circulation for the 30 and 60 mg doses, respectively (80). Moreover, co-administration of PDE-5 inhibitors with dapoxetine has no effect on the pharmacokinetics of dapoxetine (81). This favorable pharmacokinetic profile makes dapoxetine the drug of choice for on-demand treatment of PE. Dapoxetine dose-finding data have been derived from two multicentre phase II studies and used to determine the appropriate doses for phase III studies. Both studies used a randomized, placebo-controlled, double-blind, three-period, crossover study design and subjects with PE diagnosed according to https://www.recht-schaffen.de/key-practices-for-safe-usage-of-steroids/ DSM-IV criteria and a baseline IELT of less than 2 min on 75% of at least four sexual intercourse events.

There are many other SSRI medications on the market as well — but the primary use of these drugs is for treating depression. By elevating serotonin levels in synapses found in the brainstem (specifically LPGi neurons), the threshold required to achieve ejaculation is increased 4. This means men taking SSRIs need to reach a higher level of arousal to ejaculate. However, antidepressants usually take several weeks before they start producing results, and can lead to issues with dependency over time and come with a host of negative side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Cialis (tadalafil) increase increases blood flow to a certain area of the body and is used to treat …

Side Effects of Dapoxetine May Include:

The effects of Dapoxetine will last roughly 3 hours, but in some cases can last up to 12 hours. Viagra (sildenafil) is used to treat erectile dysfunction or impotence in men. Stop and get medical help at once if you have nausea, chest pain, or dizziness during sex.

• The average ejaculation time is around 5.5 minutes (based on data from over 500 couples).
• Treatment should be initiated at a dose of 30 mg and titrated to a maximum dose of 60 mg based upon response and tolerability.
• The mean half life of dapoxetine after a single dose was estimated using modelling as 1.3–1.5 h.
• However, dapoxetine appears to inhibit the ejaculatory reflex at a supraspinal level.

Who Should Avoid Dapox Tablet?

After practicing this technique for a while, the couple can move to another phase of the process. In this phase, the partners sit facing each other, with the woman’s legs crossing on top of the male’s legs. She stimulates him by manipulating his penis first close to and then with friction against her vulval area. Each time he senses excessive excitement, she applies the squeeze and stops all stimulation until he calms down enough for the process to be repeated. Dapoxetine is generally safe for individuals with normal kidney function. However, if you have any kidney-related issues, it is important to consult your healthcare provider before using this medication to ensure it is safe for you.

Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. This medication is used to treat male sexual dysfunction such as premature ejaculation.

The cause may not immediately be clear, but if there’s an obvious problem with the relationship, drug use, sexual performance anxiety, thyroid issues, or prostate dysfunction — that’s the best place to start. The most common cause of PE is anxiety — usually about sexual performance itself when having sex with a new partner. There are a lot of causes for premature ejaculation, and some incidences of PE is completely normal.